2021.11.29 03:10 UltraInstinctBeerus Easy good deed of the day (Day 648)
648. Seeking forgiveness as much as possible everyday The Prophet (Sallallahu Alaihi Wasallam) was free of all sin, but even then he has said that "I beg for Allah's forgiveness seventy times or more every day" [Bukhari]
The Prophet (Sallallahu Alaihi Wasallam) said: "Whosoever regularly seeks Allah's pardon, Allah makes for him a way out of all tight corners, removes all his worries and grants him sustenance from sources he had never imagined." [AbuDamd, Kitab-al-Satat, Bab-al-Istighfar].
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2021.11.29 03:10 Bedirhanikinci My friends and their cats☺️❤️❤️❤️
|submitted by Bedirhanikinci to KarmaConspiracy [link] [comments]|
2021.11.29 03:10 Kujo17 Identifying the spread of novel B.1.1.523 SARS-CoV-2 (NOT B1.1.529)
the following is from this article which containe full article and link to study
In their recent study, researchers from Lithuania have reported the emergence of a novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variant lineage B.1.1.523 containing a set of mutations associated with immune escape, including deletion 156_158del, substitution E484K and S494P in Spike (S) protein..
The novel SARS-CoV-2 variant lineage B.1.1.523 was added to the list of variants under the World Health Organization's Monitoring (VUM) section on July 14, 2021.
The team conducted an analysis to evaluate the origin of the newly discovered variant as well as predict potential epidemiological impacts and risks. Preliminary phylogenetic analysis indicated that this variant has a distinct viral lineage that may have originated in Russia.
A novel SARS-CoV-2 variant, classified as B.1 by PANGO, was identified containing multiple S protein mutations associated with immune escape. The variant was assigned the new phylum name B.1.1.523
At the time of concluding this study, the total number of cases with the novel variant had reached 598 in over 32 countries. It is likely that the rapid increase in circulation of the Delta variant could have diminished the rise of B.1.1.523 lineage, however, the spread of the novel SARS-CoV-2 lineage did not cease and has even started to rise.
The B.1.1.523 lineage possesses three or more mutations that characterize SARS-CoV-2 VOCs, including S:156-158 del, S:E484K and S:S494P. S:156-158 deletion at β-hairpin antigenic supersite located at the same region as that for the Delta variant (E156G and 157-158del). E484K mutation has been detected in Beta variant (B.1.351) and VUM Zeta (B.1.1.28). The mutation contributes to SARS-CoV-2 immune system evasion as evident from a significant reduction of convalescent serum neutralization. Additionally, S494P mutation is related to 3-5-fold reduced SARS-CoV-2 neutralization in sera. However, this mutation was not as potent at neutralization as E484K.
The team warns that with a combination of 158del, E484K, and S494P mutations, B1.1.523 lineage should remain on epidemiologists' watchlist as one of the most concerning SARS-CoV-2 lineages.
The maximum likelihood (ML) tree revealed several interesting properties of B.1.1.523. The base of the lineages leading to the B.1.1.523 sequences having a full set of expected S protein mutations branches away in clusters of sequences with the triple S:156_158del deletion. The sequences having the additional substitutions at S:484 and S:494 positions emerge further in the evolution. However, no clear indication was found on the sequential introduction of the mutations S:E484K, S:S494P to form the B.1.1.523 lineage.
Each Pango lineage defines a group of SARS-CoV-2 genome sequences and is created according to two guiding principles. First, Pango lineages signify groups or clusters of infections with shared ancestry. If the whole pandemic can be thought of as a vast branching tree of transmission, then Pango lineages represent the individual branches within that tree. Second, Pango lineages are intended to highlight epidemiologically-relevant events, such as the appearance of the virus in a new location, a rapid increase in cases, or the evolution of viruses with new phenotypes.From thes rules list mentioned above (i added in hyperlink) it describes :
The current rules and criteria used to create new Pango lineages can be found here and include minimum standards of lineage size, genome quality, genetic distinctiveness, and epidemiological importance. These criteria change through time, to adapt to changing needs and circumstances.
The Pango nomenclature is a hierarchical system and that is reflected in the way lineages are named. Each lineage is given a unique alphanumeric code that contains partial, but not complete, information about the phylogenetic history of that lineage. The lineage naming conventions are described here and represent a compromise between the requirements of human comprehension and machine-readability.
1c. Each full stop (or period or dot) within the numerical suffix represents “descendant of” and is applied when one ancestor of the lineage can be clearly identified (see II.1g). Example: Lineage B.1.1.7 is the seventh named descendant of lineage B.1.1, which in turn is the first named descendant of lineage B.1.Hence my speculation that this variant and Omicron must be believed to be close in lineage due to PANGO designation alone. Granted that in itself doesnt mean their traits will be the same or anything else about them will be either- bur given the discussion as to where exactly Omicron falls in the SARScov2 ancestry and this new variant was the topic of discussion prior to Omicrons naming- it seems relevant somehow
1d. In order to avoid excessively long lineage labels, the numerical suffix has a maximum of three hierarchical levels (primary, secondary and tertiary suffixes). Descendants of lineages with tertiary suffixes are assigned to the next available permitted alphabetical prefix, in alphabetical order. This new prefix acts as an alias for the name of the parental lineage. Example: The first named descendant of lineage B.1.1.1 is not named B.184.108.40.206 but is instead named C.1. The prefix C therefore serves as an alias for B.1.1.1.
2021.11.29 03:10 DueValue69 Literally every post above and below me is gay
2021.11.29 03:10 _-Careful_3m125k-_ What were they working on in the Wuhan lab IF it was a lab leak, why do they have bats why are they researching viruses?
2021.11.29 03:10 silverskybloom Intro to Speed - Chicago. Start up esk8 track days in your own cities! We have been having a freaking great time pushing and learning from each other 🤙🏻
|submitted by silverskybloom to ElectricSkateboarding [link] [comments]|
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2021.11.29 03:10 Puzzleheaded_Head588 hiii
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2021.11.29 03:10 butch_queen_reelz Found on hotel room pillow
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2021.11.29 03:10 Justsomeone109 How do I log back into my account without using my Facebook to login?
I’m level 31 and I delete the game every now and then but when I tried to login this time, it wouldn’t let me because I don’t know my password and can’t use my Facebook to login anymore because they got rid of it.
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2021.11.29 03:10 TypicalFighter [H] CYBER MONDAY DEAL!!! Any electronic you want!! I got it for a price nobody can give you!!! Phones, computers, monitors, GPUs, PS5s. I got everything and for really cheap! Brand new shipped from original company website [W] crypto or Cashapp
2021.11.29 03:10 dreamaboutdeath Nice face
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2021.11.29 03:10 pcdfranchisecompany1 List of Top 10 Pharma Companies in India
|submitted by pcdfranchisecompany1 to PrePharmacy [link] [comments]|
2021.11.29 03:10 ContentForager2 My Steam Controller setup in the basement. Great reception. (/r/SteamController)
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2021.11.29 03:10 Bane102666 .
2021.11.29 03:10 AutoNewspaperAdmin [AU] - Experts back Qld reopening plan, say no need to panic over Omicron | Sydney Morning Herald
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2021.11.29 03:10 Comfortable-Theme-87 I Made The VYBE on Wrestling Empire
2021.11.29 03:10 Barweer_MedusaChan The last 1hour and 50 minutes of Black Friday! Tick, tick, tick......
|submitted by Barweer_MedusaChan to lepin [link] [comments]|
2021.11.29 03:10 AutoNewspaperAdmin [AU] - Generosity could collide with self-interest to tackle new variants | Sydney Morning Herald
2021.11.29 03:10 BestSide301 I'm finding it harder and harder to enjoy this game
I'm lvl 50 now and I'm finding it more and more difficult to keep playing as the guns I like are getting maxed out. Im afraid that when I finally do, that will be it for me.
I find the game too redundant with how fast I'm dieing in-between each respawn. I like to play as a support or I like to try and sneak in behind the enemy. I feel like both of these playstyles just aren't there.
To infiltrate I either have to try and drive around in a vehicle and hope they didn't see me which is highly unlikely, or I im forced to use Sundance which I dont like doing and frankly she shouldn't be in this game, but even then due to the countless recon options, the second you kill 1 person, somone throws a recon grenade and now everyone knows where you are, there's no maintaining your stealth.
As for support, when I'm playing as falch, and with the high amount of deaths, I'm just constantly running around reviving and healing nonstop, I feel like the second I take my gun out, im instantly reverting back to my stim pistol to continue healing again or go revive somone. Theres no healthy mix between supporting my team with gunfire or supporting my team with health/revives.
Idk if anyone else feels this way or maybe its just me, but when I'm playing as support... I feel like I'm working a job more than im playing a game.
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2021.11.29 03:10 BrettB1997 Trying to find new people to play with who play at least somewhat regularly.
2021.11.29 03:10 capopoi How to help loved one
Hi everyone. I’m wondering if you can help me out. My mom has been struggling with chronic pain, I’m wanting to help her out. What have been the best go to treatments you guys have experienced if any? I’d love to get her a few massages/acupuncture/ anything.
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2021.11.29 03:10 exoladusmoon cute fit <3
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2021.11.29 03:10 FakeSlim_Shady 19M bored af
2021.11.29 03:10 sieg06 Domain name for sale: nikoolei.com
https://namecheap.com/domains/registration/results/?domain=nikoolei.com Nikoolei: Nee • koo • Lai Good for Tech / blockchain / NFT projects.
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